p53 as an Immune System Modulator in Cancer


Single-cell proteomics reveal drivers of immune responses, including how p53 dysfunction affects cell phenotypes in cancer

Download this poster to learn about how p53 mutations contribute to cancer phenotypes and how proteomics can be used to understand these phenotypes, courtesy of IsoPlexis.

p53 is one of the most frequently mutated genes in cancer. Because it is a cell cycle regulator, including in immune cells, p53 mutations can lead to a myriad of downstream effects in cancer. Using single-cell proteomics to understand exactly how p53 affects pro-tumorigenic and inflammatory molecules in the cancer environment, and how this proteomic profile changes with cancer therapies, can help advance our current understanding and treatment of cancer.

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