---
title: Designing More Resilient Cancer CAR-T Therapy
description: This webinar discusses CAR-T cell cancer therapy, including its benefits, treatment schema, case studies involving treatment failure, and what functional assays tell us about designing CAR-T therapies with continued efficacy.
image: https://go.clinicallab.com/hubfs/IsoPlexis%20webinar%20735x200-Hubspot-1.png
---

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Speaker

![David Miklos.jpg](https://go.clinicallab.com/hubfs/David%20Miklos%20200x200.png "David Miklos")

David Miklos  
MD, PhD

# Sharpening a Double-Edged Sword: Bispecific CAR-T Cancer Therapies

Chimeric antigen receptor T-cell (CAR-T) therapy targeting the surface receptor CD19 (CAR19) is a potent treatment option for patients with relapsed or chemotherapy-refractory B cell malignancies. Unfortunately, cancer continues to progress in a large subset of these patients due to changes in CD19 presentation on cancer cells.

To eliminate malignant B cells with low CD19 levels, researchers have developed CAR therapies that target the B-cell specific cell surface molecule CD22. While sequential CAR therapy has shown limited success, scientists have now developed a bispecific CAR T-cell that simultaneously targets CD19 and CD22.

In this webinar brought to you by IsoPlexis, David Miklos will discuss recent advances in bispecific CAR-T therapy development and critical functional biomarkers for characterizing CAR-T product quality.

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### Sharpening a Double-Edged Sword: Bispecific CAR-T Cancer Therapies

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